A newly developed “living bandage” may represent a major leap forward in wound care, according to new research from Rice University in Texas.

The innovative patch, which continuously releases healing proteins directly onto wounds, was described by SWNS as operating like a mini biological factory that stays active around the clock.

Chronic wounds are notoriously difficult to treat because most conventional methods cannot sustain the delicate chemical signals that guide tissue repair.

The Rice team focused on solving that problem by engineering a system capable of long-term, localized protein delivery.

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The body’s own healing process depends heavily on molecules called cytokines, which regulate inflammation and repair.

Traditional therapies such as ointments or protein injections often fall short because these molecules tend to degrade quickly or are washed away before they can take effect.

The researchers designed a new cell-based bandage that wears like a patch placed directly over the wound site.

Inside it are engineered cells that produce three types of key cytokines — IL-10, IL-12, and Transforming Growth Factor-beta — that help drive the body’s recovery mechanisms.

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These engineered cells are protected within a specialized material that lets nutrients and therapeutic proteins move freely to the skin while shielding the cells from immune system attacks. The design ensures continuous release of healing factors without triggering rejection responses.

A hydrogel component allows the device to blend seamlessly with the wound surface, maintaining contact as tissue regeneration occurs. The team suggested that future models could incorporate electronic systems to further enhance control.

Experiments on rodents and pigs demonstrated that the bandage accelerated tissue repair. Genetic analysis confirmed that the treatment activated specific pathways tied to wound recovery and immune modulation.

Professor Omid Veiseh, the Rice Biotech Launch Pad faculty director and project leader, said the results underscore the potential of continuous cytokine delivery to promote natural healing.

“By maintaining a consistent presence of these signaling molecules at the wound site, we can more effectively engage the body’s natural healing response,” the team explained.

Veiseh noted that the findings “show how continuous, localized cytokine delivery can support key biological pathways involved in tissue repair,” and that genetic data revealed “coordinated upregulation of genes associated with tissue regeneration and immune modulation.”

Researcher Elizabeth Kelley was photographed holding the cytokine-secreting bandage used in the experiments, underscoring how the patch can be handled and adapted for various test conditions.

The platform can be customized so that the cells inside generate different combinations of proteins and growth factors, enabling physicians to modify the therapy for different patients or injuries.

Co-author Christian Schreib, Ph.D., said the design’s flexibility allows researchers to adjust both the timing and type of cytokine production, potentially giving doctors precise control over each stage of recovery.

“Future work will focus on expanding the flexibility of the platform, including approaches such as optogenetic control,” Schreib explained, referring to a light-based method that could regulate cytokine secretion in real time.

While the approach remains in early development, it has not yet been tested in human patients. The researchers said further studies will determine how the system performs in clinical settings.

The work was published in the journal Nature Biomedical Engineering, marking another step forward in the intersection of biotechnology and advanced wound care.